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  • 沙芬酰胺

    (2S)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]propanamide

化合物简介

Safinamide (INN; brand name Xadago, former developmental code name EMD-1195686) is a drug indicated for the treatment of Parkinson's disease with multiple methods of action. In 2007, a Phase III clinical trial was started. It was scheduled to run until 2011. The compound was originally discovered at Farmitalia-Carlo Erba, first published in 1998 and developed by Newron Pharmaceuticals, which sold the rights to Merck-Serono in 2006. In October 2011 Merck-Serono announced that they would give all rights to develop the compound back to Newron.

基本信息

CAS:133865-89-1
中文别名:(S)-2-[[4-[(3-氟苯甲基)氧]苯甲基]氨基]丙酰胺;
英文别名:(S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propionamide;(S)-(+)-2-[4-(3-fluorobenzyloxy)benzylamino]-propanamide;(2S)-2-[4-(3-fluorobenzyloxy)benzylamino]propionamide;Safinamide;
分子式:C17H19FN2O2
分子量:302.343
精确质量:302.143
Psa:64.35
Logp:3.4593

编号系统

UNII:90ENL74SIG

物化性质

密度:1.189 g/cm3
沸点:476.7ºC at 760 mmHg
折射率:1.569
蒸汽压:2.98E-09mmHg at 25°C

安全信息

生产方法及用途

合成路线

上游原料

下游产品

图谱

13C NMR : Predict


1H NMR : Predict


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