MG132 is a specific, potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). It reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. MG132 activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. MG132 also inhibits NF-κB activation with an IC50 of 3 µM and prevents β-secretase cleavage.

CAS：133407-82-6
中文别名：Z-LEU-LEU-LEU-AL;蛋白酶体抑制剂;
英文别名：Z-Leu-Leu-Leu-H;benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate;Z-LLL-CHO;Cbz-Leu-Leu-Leu-H;Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal;N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal;Z-Leu-Leu-Leu-CHO;
分子式：C26H41N3O5
分子量：475.621
精确质量：475.305
Psa：113.6
Logp：4.7609

MDL号：MFCD00674886
PubChem号：24892475

外观与性状：白色至灰白色粉末
密度：1.073 g/cm3
沸点：682ºC at 760 mmHg
闪点：366.3ºC
折射率：1.506
储存条件：-20ºC
蒸汽压：1.86E-18mmHg at 25°C