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比折来新
1,3-bis[2-[(8S)-8-(chloromethyl)-4-hydroxy-1-methyl-7,8-dihydro-3H-pyrrolo[3,2-e]indole-6-carbonyl]-1H-indol-5-yl]urea
化合物简介
As members of the cyclopropylpyrroloindole family, Adozelesin and Bizelesin cause genomic DNA lesions by alkylating DNA. Adozelesin induces single-strand DNA lesions, whereas Bizelesin induces both single-strand lesions and double-strand DNA cross-links. Thus, despite similar abilities to alkylate DNA, the chemotherapeutic agents Adozelesin and Bizelesin caused a decrease in HCT116 tumor cell proliferation by different pathways (i.e., Adozelesin induced apoptosis, and Bizelesin induced senescence).
基本信息
CAS：129655-21-6
中文别名：
英文别名：Benzo(1,2-b:4,3-b\')dipyrrol-4-ol,6,6\'-(carbonylbis(imino-1H-indole-5,2-diylcarbonyl))bis(8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-,(S-(R*,R*));U-77,779;BIZELESIN;Bizelesin (USAN/INN);
分子式：C43H36Cl2N8O5
分子量：815.703
精确质量：814.219
Psa：185.37
Logp：9.5254
中文别名：
英文别名：Benzo(1,2-b:4,3-b\')dipyrrol-4-ol,6,6\'-(carbonylbis(imino-1H-indole-5,2-diylcarbonyl))bis(8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-,(S-(R*,R*));U-77,779;BIZELESIN;Bizelesin (USAN/INN);
分子式：C43H36Cl2N8O5
分子量：815.703
精确质量：814.219
Psa：185.37
Logp：9.5254
编号系统
UNII：L0O9OBI87E
物化性质
密度：1.604g/cm3
折射率：1.856
折射率：1.856
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
1H NMR : Predict
13C NMR : Predict
