(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is an intermediate in the synthesis of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.

CAS：127852-28-2
中文别名：R-1-[3,5-双(三氟甲基)苯基]乙醇;(R)-1-[3,5-双(三氟甲基)苯基]乙醇;(R)-1-[3,5-二(三氟甲基)苯基]乙醇;
英文别名：(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-ol;(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethyl Alcohol;(R)-3,5-Bis(trifluoromethyl)-α-methylbenzyl Alcohol;(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol;(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol;R-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol;
分子式：C10H8F6O
分子量：258.16
精确质量：258.048
Psa：20.23
Logp：3.7775

MDL号：MFCD03093010

密度：1.376 g/cm3
沸点：175.8ºC at 760 mmHg
闪点：60.1ºC
折射率：1.418
蒸汽压：0.746mmHg at 25°C

安全说明：S26
危险类别码：R36/37/38
海关编码：2906299090
危险品标志：Xi

用途
阿瑞匹坦的中间体。