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  • (3S)-3-苯基-3-[4-(三氟甲基)苯氧基]-1-丙胺

    (3S)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine

化合物简介

Seproxetine, also known as (S)-norfluoxetine, is a selective serotonin reuptake inhibitor (SSRI). It is the most important active metabolite of the widely used antidepressant fluoxetine, but little is known about its pharmacological actions. Seproxetine was being investigated by Eli Lilly and Company as an antidepressant; however, a cardiac side effect was noted and development was discontinued.

基本信息

CAS:126924-38-7
中文别名
英文别名:UNII-25CO3X0R31;SEPROXETINE;
分子式:C16H16F3NO
分子量:295.3
精确质量:295.118
Psa:35.25
Logp:4.8746

编号系统

物化性质

密度:1.204g/cm3
沸点:381.1ºC at 760 mmHg
闪点:184.3ºC
折射率:1.525
蒸汽压:5.21E-06mmHg at 25°C

安全信息

海关编码:2922299090

生产方法及用途

合成路线

  • 参考文献

    HUMAN BIOMOLECULAR RESEARCH INSTITUTE Patent: WO2006/25920 A2, 2006 ; Location in patent: Page/Page column 148-149 ; WO 2006/025920 A2

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图谱

13C NMR : Predict


1H NMR : Predict


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