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化合物简介
Venetoclax (INN, trade name Venclexta ven-KLEKS-tuh, previously known as GDC-0199, ABT-199, and RG7601) is a small molecule oral drug being investigated to treat chronic lymphocytic leukemia (CLL). In 2015, the United States Food and Drug Administration (FDA) granted Breakthrough Therapy Designation to venetoclax for patients with CLL who have relapsed or have been refractory to previous treatment and have the 17p deletion genetic mutation.
基本信息
CAS:1257044-40-8
中文别名:维奈妥拉;
英文别名:Venclexta (US Trade name);Venclyxto (EU Trade name);GDC-0199;ABT-199;RG7601;4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[3-nitro-4-(oxan-4-ylmethylamino)phenyl]sulfonyl-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide;GDC0199;CS-1155;UNII-N54AIC43PW;
分子式:C45H50ClN7O7S
分子量:868.439
精确质量:867.318
Psa:183.09
Logp:10.7307
中文别名:维奈妥拉;
英文别名:Venclexta (US Trade name);Venclyxto (EU Trade name);GDC-0199;ABT-199;RG7601;4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[3-nitro-4-(oxan-4-ylmethylamino)phenyl]sulfonyl-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide;GDC0199;CS-1155;UNII-N54AIC43PW;
分子式:C45H50ClN7O7S
分子量:868.439
精确质量:867.318
Psa:183.09
Logp:10.7307
编号系统
UNII:N54AIC43PW
物化性质
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
1H NMR : Predict

13C NMR : Predict
