Dorsomorphin is an AMP-activated kinase (AMPK) inhibitor. Dorsomorphin selectively inhibits the bone morphogenetic protein (BMP) type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation. Dorsomorphin has shown to to increase cisplatin-induced apoptosis, which was associated with hyper-induction of the tumor suppressor p53.

CAS：1219168-18-9
中文别名：
英文别名：6-[4-[2-(1-PIPERIDINYL)ETHOXY]PHENYL]-3-(4-PYRIDINYL)-PYRAZOLO[1,5-A]PYRIMIDINE DIHYDROCHLORIDE;Dorsomorphin 2HCl;FD5027;Dorsomorphin dihydrochloride;S7306,BML-275,Compound C;
分子式：C24H27Cl2N5O
分子量：472.41
精确质量：471.159
Psa：55.55
Logp：5.8649

外观性状：固体
储存条件：室温，干燥，密封