Anastrozole (INN) (marketed under the trade name Arimidex by AstraZeneca) is a non-steroidal aromatase-inhibiting drug approved for treatment of breast cancer after surgery, as well as for metastasis in both pre and post-menopausal women. The severity of breast cancer can be increased by estrogen, as sex hormones cause hyperplasia, and differentiation at estrogen receptor sites. Anastrozole works by inhibiting the synthesis of estrogen. The patent on Arimidex by AstraZeneca expired June 2010.

CAS：120511-73-1
中文别名：阿拉曲唑;阿纳曲唑;四甲基-5-(1H-1,2,4-三唑-1-基甲基)-1,3-苯二乙腈;ICI一1)1033:ADRLLIDEX;阿那罗唑;阿那舒唑;盐酸纳美芬;盐酸纳美芬.盐酸钠美芬;
英文别名：ANASTRAZOLE;Anastrol;Anatrozole;ZD-1033;1,3-benzenediacetonitrile;Anastrozol;2,2\'-(5-((1H-1,2,4-Triazol-1-yl)methyl)-1,3-phenylene)bis(2-methylpropanenitrile);ICI-D-1033;ARIMIDEX;4-Triazol-1-ylmethyl)-1;Anastrozole;Anastrolozole;
分子式：C17H19N5
分子量：293.366
精确质量：293.164
Psa：78.29
Logp：2.92876

RTECS号：CZ1465000

外观与性状：结晶固体
密度：1.08 g/cm3
沸点：469.7ºC at 760 mmHg
熔点：81-82°C
折射率：1.791
储存条件：Store in original container in a cool dark place.

安全说明：S26; S37/39
危险类别码：R36/37/38
危险品运输编码：3249
海关编码：2933990090
危险类别：6.1(b)
包装等级：III
危险品标志：Xi

生产方法
1.化合物(I)(有制备方法)经N-溴代丁二酰亚胺(NBS)溴化，生成物(II)用三唑钠处理，即得产物。 第三代芳香酶抑制剂。用于治疗绝经后的晚期乳腺癌病人。
用途
第三代芳香酶抑制剂。用于治疗绝经后的晚期乳腺癌病人。