J 147 is a novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. J 147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer's disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques.

CAS：1146963-51-0
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分子式：C18H17F3N2O2
分子量：350.335
精确质量：350.124
Psa：41.9
Logp：4.2414

密度：1.2±0.1g/cm3
沸点：412.8±55.0°Cat760mmHg
闪点：203.5±31.5°C
外观性状：lightyellowsolid
蒸汽压：0.0±1.0mmHgat25°C
折射率：1.515
储存条件：-20℃