N-Glycolylneuraminic acid (Neu5Gc) is a sialic acid molecule found in most mammals. Humans cannot synthesize Neu5Gc because the human gene CMAH is irreversibly mutated, though it is found in apes. It is absent in human tissues because of inactivation of gene encoding CMP-N-acetylneuraminic acid hydroxylase. The gene CMAH encodes for CMP-N-acetylneuraminic acid hydroxylase, which is the enzyme responsible for CMP-Neu5Gc from CMP-N-acetylneuraminic (CMP-Neu5Ac) acid. This loss of the CMAH was estimated to have occurred two to three millions of years ago, which occurred just before the emergence of the genus Homo.

CAS：1113-83-3
中文别名：
英文别名：N-glycoloyl-beta-neuraminic acid;N-Glykoloyl-neuraminsaeure;Glycolylneuraminic Aci;N-Glycolylneuraminic Acid (200 mg);N-Glykolyl-neuraminsaeure;Neu5Glc NeuNGl;Neu5Glc,NeuNGl;Glycolylneuraminic Acid;5-Glykoloylamino-D-glycero-D-galacto-3,5-didesoxy-[2]nonulonsaeure;N-GLYCOLYLNEURAMINIC ACID FROM PORCINE*SUBMAXILLARY;N-Glycolylneuraminic Acid;N-GLYCOLYNEURAMINIC ACID;N-(2-Hydroxyacetyl)-neuraminic Acid;N-Glycolyl Neuraminic Acid;N-glycoylneuraminic acid;N-(Hydroxyacetyl)neuraminic acid;N-glycoloyl-neuraminic acid;N-Glycolylneuraminic acid;
分子式：C11H19NO10
分子量：325.269
精确质量：325.101
Psa：197.01
Logp：-4.5085

PubChem号：24873386
MDL号：MFCD00057551

外观与性状：白色至灰白色粉末
密度：1.75 g/cm3
沸点：884.2ºC at 760 mmHg
熔点：188-190°C
闪点：488.6ºC
折射率：1.62
储存条件：-20ºC
蒸汽压：3.24E-34mmHg at 25°C

WGK Germany：3