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荧光钙探针 Fura 2-AM
acetyloxymethyl 2-[5-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]-4-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]-5-methylphenoxy]ethoxy]-1-benzofuran-2-yl]-1,3-oxazole-5-carboxylate
化合物简介
Fura-2-acetoxymethyl ester, often abbreviated Fura-2AM, is a membrane-permeable derivative of the ratiometric calcium indicator Fura-2 used in biochemistry to measure cellular calcium concentrations by fluorescence. When added to cells, Fura-2AM crosses cell membranes and once inside the cell, the acetoxymethyl groups are removed by cellular esterases. Removal of the acetoxymethyl esters regenerates \"Fura-2\", the pentacarboxylate calcium indicator. Measurement of Ca2+-induced fluorescence at both 340 nm and 380 nm allows for calculation of calcium concentrations based 340/380 ratios. The use of the ratio automatically cancels out certain variables such as local differences in fura-2 concentration or cell thickness that would otherwise lead to artifacts when attempting to image calcium concentrations in cells.
基本信息
CAS：108964-32-5
中文别名：AM荧光探针;钙离子荧光探针 Fura 2-AM;荧光钙探针Fura2-AM;FURA 2-AM SPECIAL PACKAGING;
英文别名：Fura 2am;Fura-2 pentakis(acetoxymethyl) ester;
分子式：C44H47N3O24
分子量：1001.85
精确质量：1001.25
Psa：327.11
Logp：2.3994
中文别名：AM荧光探针;钙离子荧光探针 Fura 2-AM;荧光钙探针Fura2-AM;FURA 2-AM SPECIAL PACKAGING;
英文别名：Fura 2am;Fura-2 pentakis(acetoxymethyl) ester;
分子式：C44H47N3O24
分子量：1001.85
精确质量：1001.25
Psa：327.11
Logp：2.3994
编号系统
MDL号：MFCD00036976
PubChem号：24894734
BRN号：8183748
PubChem号：24894734
BRN号：8183748
物化性质
密度：1.4g/cm3
沸点：975.9ºC at 760mmHg
闪点：544ºC
折射率：1.566
储存条件：-20ºC
蒸汽压：0mmHg at 25°C
沸点：975.9ºC at 760mmHg
闪点：544ºC
折射率：1.566
储存条件：-20ºC
蒸汽压：0mmHg at 25°C
安全信息
WGK Germany：3