A specific serotonin (5HT3) receptor antagonist. Used as an antiemetic. Granisetron HCl is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptor

CAS：107007-99-8
中文别名：1-甲基-N-[内向-9-甲基-9-氮杂双环(3,3,1)壬烷-3-基]-lH-吲唑-3-甲酰胺盐酸盐;N-(内-9-甲基-9-氮杂二环[3,3,1]壬-3-基)-吲哚-3-羧酰胺盐酸盐;1-甲基-N-[内向-9-甲基-9-氮杂双环[3.3.1]壬烷-3-基]-1H-吲唑-3-甲酰胺盐酸盐;格拉司琼盐酸盐;桥-N-(9-甲基-9-氯杂二环[3.3.1]壬-3-基)-1-甲基-1H-吲唑-3-羧酰胺盐酸盐;1-甲基-N-[(3-endo)-9-甲基-9-氮杂双环[3.3.1]壬-3-基]-1H-吲哚-3-甲酰胺盐酸盐;
英文别名：1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide;1-methyl-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide,hydrochloride;Granisetron Hydrochloride;
分子式：C18H25ClN4O
分子量：348.87
精确质量：348.172
Psa：50.16
Logp：3.4492

MDL号：MFCD01747034
RTECS号：NK7882200

外观与性状：白色至灰白色结晶固体
密度：1.33g/cm3
沸点：532ºC at 760mmHg
熔点：290-292°C
闪点：275.6ºC
折射率：1.69
储存条件：Room temp
蒸汽压：0mmHg at 25°C

RTECS号：NK7882200
安全说明：S26; S36; S37
危险类别码：R22
海关编码：2933990090
危险品标志：Xn; Xi

生产方法
化合物(I)和化合物(Ⅱ)反应，即得格拉司琼。用氯化氢-乙醇酸化，得到盐酸格拉司琼。 5-HT3受体拮抗剂，止吐药，用于治疗或化疗引起的呕吐。
用途
5-HT3受体拮抗剂，止吐药，用于治疗或化疗引起的呕吐。