WYE 354; 4-[6-[4-[(甲氧羰基)氨基]苯基]-4-(4-吗啉基)-1H-吡唑并[3,4-d]嘧啶-1-基]-1-哌啶羧酸甲酯 methyl 4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate CAS号1062169-56-5分子式、结构式、MSDS、物化性质、用途-化学科研者一站式服务平台

化合物简介

A pyrazolopyrimidines derivative that is a potent and ATP-competitive mTOR inhibitor with much reduced activity against PI 3-Kα or PI 3-Kγ. WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and Akt as the respective substrate (IC50 <200 nM; [ATP] = 100 µM) and effectively blocks cellular phosphorylation of S6K on T389 and Akt on S473 both in cultures and in a murine xenograft model, resulting in a significant suppression of PC3MM2-derived tumor growth (by 86% on day 7; 50 mg/kg, i.p twice per day) in vivo.

基本信息

CAS：1062169-56-5
中文别名：
英文别名：pyrazolo pyrimidine,19;WYE354;
分子式：C24H29N7O5
分子量：495.531
精确质量：495.223
Psa：123.94
Logp：2.9874

编号系统

物化性质

密度：1.5±0.1g/cm3
沸点：594.2±50.0°Cat760mmHg
闪点：313.2±30.1°C
蒸汽压：0.0±1.7mmHgat25°C
折射率：1.692
储存条件：-20°C

安全信息

生产方法及用途

合成路线

上游原料

下游产品

图谱

1H NMR : Predict

13C NMR : Predict

化学科研者一站式服务平台

WYE 354; 4-[6-[4-[(甲氧羰基)氨基]苯基]-4-(4-吗啉基)-1H-吡唑并[3,4-d]嘧啶-1-基]-1-哌啶羧酸甲酯methyl 4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate