Linopirdine is a putative cognition-enhancing drug with a novel mechanism of action. Linopirdine blocks the KCNQ2\\3 heteromer M current with an IC50 of 2.4nM disinhibiting acetylcholine release, and increasing hippocampal CA3-schaffer collateral mediated glutamate release onto CA1 pyramidal neurons. In a murine model linopirdine is able to nearly completely reverse the senescence-related decline in cortical c-FOS, an effect which is blocked by atropine and MK-801, suggesting Linopirdine can compensate for the age related decline in acetylcholine release. Linopirdine also blocks homomeric KCNQ1 and KCNQ4 voltage gated potassium channels which contribute to vascular tone with substantially less selectivity than KCNQ2/3.

CAS：105431-72-9
中文别名：1,3-二氢-1-苯基-3,3-双(4-吡啶甲基)-2H-吲哚-2-酮双盐酸盐;
英文别名：linopiridine;Dup 996;Linopirdine;
分子式：C26H21N3O
分子量：391.464
精确质量：391.168
Psa：46.09
Logp：4.9431

UNII：I5TB3NZ94T

密度：1.255 g/cm3
沸点：655.9ºC at 760 mmHg
闪点：350.5ºC
折射率：1.669
蒸汽压：4.45E-17mmHg at 25°C

海关编码：2933790090