Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells.\nProtein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.

CAS：10540-29-1
中文别名：(Z)-2-[4-(1,2-二苯基-1-丁烯)苯氧基]-N,N-二甲基乙胺;氮位N-去甲基盐酸三苯氧胺;它莫西芬;
英文别名：[3H]-Tamoxifen;Oncomox;Soltamox;Crisafeno;trans-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine;Valodex;Citofen;Tamoxifen;Diemon;Tamoxifene;2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine;(Z)-1-{4-[2-(dimethylamino)ethoxy]-phenyl}-1,2-diphenyl-1-butene;[14C]-Tamoxifen;Tamoxen;Tamizam;
分子式：C26H29NO
分子量：371.515
精确质量：371.225
Psa：12.47
Logp：5.9961

RTECS号：KR5919600
MDL号：MFCD00010454
PubChem号：24900307
EINECS号：234-118-0

外观与性状：细灰白色结晶粉末
密度：1.042 g/cm3
熔点：97-98ºC
闪点：140ºC
折射率：1.582
储存条件：2-8ºC
蒸汽压：1.85E-09mmHg at 25°C

RTECS号：KR5919600
安全说明：S53-S45
WGK Germany：3
危险类别码：R45; R60; R61; R64
海关编码：2922199090
危险品标志：T
危险性描述：H350; H360; H362
危险标志：GHS08
危险性防范说明：P201; P263; P308 + P313
信号词：Danger

用途
用于治疗晚期乳腺癌，对卵巢癌也有效，与其他抗癌药合用效果更好。