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    Tetrahydropalmatine

化合物简介

Tetrahydropalmatine (THP) is an alkaloid found in several different plant species, mainly in the Corydalis genus (Yan Hu Suo), but also in other plants such as Stephania rotunda. These plants have traditional uses in Chinese herbal medicine. The pharmaceutical industry has synthetically produced the more potent enantiomer Levo-tetrahydropalmatine (Levo-THP), which has been marketed worldwide under different brand names as an alternative to anxiolytic and sedative drugs of the benzodiazepine group and analgesics such as opiates. It is also sold as a dietary supplement.

基本信息

CAS:10097-84-4
中文别名:左旋延胡索乙素;左旋四氢巴马汀;2,3,9,10-四甲氧基-5,8,13,13a-四氢-6H-二苯并[a,g]喹嗪;
英文别名:D-Tetrahydropalmatin;levo-tetrahydropalmatine;Levo?tetrahydropalmatine;
分子式:C21H25NO4
分子量:355.428
精确质量:355.178
Psa:40.16
Logp:3.3144

编号系统

物化性质

密度:1.23 g/cm3
沸点:482.9ºC at 760 mmHg
闪点:138.7ºC
折射率:1.608
蒸汽压:1.76E-09mmHg at 25°C

安全信息

生产方法及用途

用途
用作镇痛药,适用于内科疾病引起的胃肠道和肝胆系统的头痛、痛经及分娩止痛

合成路线

上游原料

下游产品

图谱

13C NMR : Predict


1H NMR : Predict


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