(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone is a highly selective AKT inhibitor targeting Akt1, Akt2 and Akt3. Studies have shown its use in combination with vemurafenib, have demonstrated therapeutic value in the treatment of hyperproliferative disorders such as cancer.

CAS：1001264-89-6
中文别名：
英文别名：RG 7440;GDC-0068;(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one;
分子式：C24H32ClN5O2
分子量：457.996
精确质量：457.224
Psa：81.59
Logp：3.4948

MDL号：MFCD22124514

密度：1.3±0.1g/cm3
沸点：669.4±55.0°Cat760mmHg
闪点：358.7±31.5°C
外观性状：粉末
蒸汽压：0.0±2.1mmHgat25°C
折射率：1.603
储存条件：-20℃
水溶解性：SolubleinDMSO.